Description
Product Characteristics:
Subcellular location: Cytoplasm, Nucleus
Synonyms: Arg/Glu/Asp rich protein, 120 kDa, Arg/Glu/Asp-rich protein of 120 kDa, fSAP94, functional spliceosome-associated protein 94, NET52, Protein S164, Rbm25, RBM25_HUMAN, RED120, RNA binding motif protein 25, RNA binding region (RNP1, RRM) containing 7, RNA-binding motif protein 25, RNA-binding protein 25, RNA-binding region-containing protein 7, RNPC7, S164, Snu71, U1 small nuclear ribonucleoprotein 1SNRP homolog.
Target Information: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA (By similarity)